RT Journal Article
SR Electronic
T1 DeepMetabolism: A Deep Learning System to Predict Phenotype from Genome Sequencing
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 135574
DO 10.1101/135574
A1 Guo, Weihua
A1 Xu, You (Eric)
A1 Feng, Xueyang
YR 2017
UL http://biorxiv.org/content/early/2017/05/09/135574.abstract
AB Life science is entering a new era of petabyte-level sequencing data. Converting such “big data” to biological insights represents a huge challenge for computational analysis. To this end, we developed DeepMetabolism, a biology-guided deep learning system to predict cell phenotypes from transcriptomics data. By integrating unsupervised pre-training with supervised training, DeepMetabolism is able to predict phenotypes with high accuracy (PCC>0.92), high speed (<30 min for >100 GB data using a single GPU), and high robustness (tolerate up to 75% noise). We envision DeepMetabolism to bridge the gap between genotype and phenotype and to serve as a springboard for applications in synthetic biology and precision medicine.