RT Journal Article
SR Electronic
T1 Lifespan Oscillatory Dynamics in Lexical Production: A Population-based MEG Resting-State Analysis
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2024.07.28.605484
DO 10.1101/2024.07.28.605484
A1 Guichet, Clément
A1 Harquel, Sylvain
A1 Achard, Sophie
A1 Mermillod, Martial
A1 Baciu, Monica
YR 2024
UL http://biorxiv.org/content/early/2024/07/29/2024.07.28.605484.abstract
AB Lexical production remains relatively preserved across the lifespan, but cognitive control demands increase with age to support efficient semantic access. It suggests a domain-general and a language-specific component. Current neurocognitive models suggest the Default Mode Network (DMN) may drive the interplay between these components, impacting the trajectory of production performance with a pivotal shift around midlife. However, the corresponding time-varying architecture still needs clarification. Here, we leveraged MEG resting-state data from healthy adults aged 18-88 from a CamCAN population-based sample. We found that DMN temporal dynamics shift from anterior-ventral to posterior-dorsal states until midlife to mitigate word-finding challenges. Similarly, sensorimotor integration along this posterior path enhances cross-talk with lower-level circuitry as the dynamic information flow with more anterior, higher-order cognitive states gets compromised. It suggests a bottom-up, exploitation-based form of cognitive control in the aging brain, highlighting the interplay between abstraction, control, and perceptive-motor systems in preserving lexical production.HighlightsMidlife is a pivotal period for time-varying functional connectivityDMN activation and deactivation drive the resting-state oscillatory architectureEnhanced posterior DMN temporal dynamics mitigates lexical production declineCompeting Interest StatementThe authors have declared no competing interest.