PT  - JOURNAL ARTICLE
AU  - Veillette, John P.
AU  - Nusbaum, Howard C.
TI  - What the Average Really Means: Dissociating Effect Size and Effect Prevalence using <em>p</em>-curve Mixtures
AID  - 10.1101/2024.07.31.606048
DP  - 2024 Jan 01
TA  - bioRxiv
PG  - 2024.07.31.606048
4099  - http://biorxiv.org/content/early/2024/08/01/2024.07.31.606048.short
4100  - http://biorxiv.org/content/early/2024/08/01/2024.07.31.606048.full
AB  - Most research in the behavioral sciences aims to characterize effects of interest using sample means intended to describe the “typical” person. A difference in means is usually construed as a size difference in an effect common across subjects. However, mean effect size varies with both within-subject effect size and population prevalence (proportion of population showing the effect) in compared groups or across conditions. Few studies consider how prevalence affects mean effect size measurements and existing estimators of prevalence are, conversely, confounded by uncertainty about within-subject power. We introduce a widely applicable Bayesian method, the p-curve mixture model, that jointly estimates prevalence and effect size. Our approach outperforms existing prevalence estimation methods when within-subject power is uncertain and is sensitive to differences in prevalence or effect size across groups or experimental conditions. We present examples, extracting novel insights from existing datasets, and provide a user-facing software tool.Competing Interest StatementThe authors have declared no competing interest.