RT Journal Article
SR Electronic
T1 Brain structural differences between 73- and 92-year olds matched for childhood intelligence, social background, and intracranial volume
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 135871
DO 10.1101/135871
A1 Stuart J. Ritchie
A1 David Alexander Dickie
A1 Simon R. Cox
A1 Maria del C. Valdés Hernández
A1 Alison Pattie
A1 Devasuda Anblagan
A1 Paul Redmond
A1 Natalie A. Royle
A1 Janie Corley
A1 Susana Muñoz Maniega
A1 Adele M. Taylor
A1 Sherif Karama
A1 Tom Booth
A1 Alan J. Gow
A1 John M. Starr
A1 Mark E. Bastin
A1 Joanna M. Wardlaw
A1 Ian J. Deary
YR 2017
UL http://biorxiv.org/content/early/2017/05/09/135871.abstract
AB Fully characterizing age differences in the brain is a key task for combatting ageing-related cognitive decline. Using propensity score matching on two independent, narrow-age cohorts, we used data on childhood cognitive ability, socioeconomic background, and intracranial volume to match participants at mean age 92 years (n = 42) to very similar participants at mean age 73 (n = 126). Examining a variety of global and regional structural neuroimaging variables, there were large differences in grey and white matter volumes, cortical surface area, cortical thickness, and white matter hyperintensity volume and spatial extent. In a mediation analysis, the total volume of white matter hyperintensities and total cortical surface area jointly mediated 24.9% of the relation between age and general cognitive ability (tissue volumes and cortical thickness were not significant mediators in this analysis). These findings provide an unusual and valuable perspective on neurostructural ageing, in which brains from the eighth and tenth decades of life differ widely despite the same cognitive, socio-economic, and brain-volumetric starting points.