RT Journal Article
SR Electronic
T1 Protein features identification for machine learning-based prediction of protein-protein interactions
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 137257
DO 10.1101/137257
A1 Khalid Raza
YR 2017
UL http://biorxiv.org/content/early/2017/05/12/137257.abstract
AB The long awaited challenge of post-genomic era and systems biology research is computational prediction of protein-protein interactions (PPIs) that ultimately lead to protein functions prediction. The important research questions is how protein complexes with known sequence and structure be used to identify and classify protein binding sites, and how to infer knowledge from these classification such as predicting PPIs of proteins with unknown sequence and structure. Several machine learning techniques have been applied for the prediction of PPIs, but the accuracy of their prediction wholly depends on the number of features being used for training. In this paper, we have performed a survey of protein features used for the prediction of PPIs. The open research challenges and opportunities in the area have also been discussed.