RT Journal Article SR Electronic T1 Ultrashort-T2* mapping at 7 tesla using an optimized pointwise encoding time reduction with radial acquisition (PETRA) sequence at standard and extended echo times JF bioRxiv FD Cold Spring Harbor Laboratory SP 2024.09.05.611365 DO 10.1101/2024.09.05.611365 A1 Lockard, Carly A. A1 Damon, Bruce M. A1 Serrai, Hacene YR 2024 UL http://biorxiv.org/content/early/2024/09/11/2024.09.05.611365.abstract AB Zero echo time (ZTE) sequences capture signal from tissues with extremely short T2* and are useful for qualitative and quantitative imaging of musculoskeletal tissues’ ultrashort-T2* components. One such sequence is Pointwise Encoding Time Reduction with Radial Acquisition (PETRA). While this sequence has shown promising results, it has undergone only limited testing at 7 tesla (T). The purpose of this work was to evaluate PETRA at 7T in its standard form and with sequence modifications to allow extended echo times for the purpose of performing ultrashort-T2* mapping.We acquired PETRA images of MnCl2 and collagen phantoms and of the knee in eight participants (5 for optimization and 3 for ultrashort-T2* mapping assessment; 5 male/3 female, 39 ± 11 years old). Images were acquired using a 1-transmit/28-receive-channel knee coil. Artifacts, signal, signal-to-noise ratio (SNR), ultrashort-T2*, the corresponding curve fit quality, and repeatability were assessed. SNR was high in knee tissues at TE = 0.07 msec compared to a conventional-TE sequence (Dual-Echo Steady State with TE = 2.55 msec), with values ranging between 68 to 337 across the assessed tissues for PETRA versus 16 to 30 for the same tissue regions of interest in the conventional-TE series. Acquisition of series for ultrashort-T2* maps was feasible at 1.50 mm isotropic acquisition resolution and TE ≤ 0.58 msec. Strong linear correlations were observed between relaxation times and MnCl2 concentration, and between signal and collagen concentration. Ultrashort-T2* signal decay curve fit R2 and repeatability were high for phantom and knee ultrashort-T2* <1 msec.PETRA imaging with minimal artifacts, high SNR, and scan time < 11 minutes was achieved at 7T at high (0.34 mm isotropic) resolution at TE = 0.07 msec and lower resolution (1.52 mm isotropic) at echo times ≤ 0.58 msec. Ultrashort-T2* mapping provided acceptable curve-fitting results for substances with sub-millisecond T2*.Competing Interest StatementThe authors have declared no competing interest.