TY - JOUR T1 - Diet and life stage associated remodeling of lipid metabolism regulation in the duplicated Atlantic salmon genome JF - bioRxiv DO - 10.1101/140442 SP - 140442 AU - Gareth Gillard AU - Thomas N. Harvey AU - Arne Gjuvsland AU - Yang Jin AU - Magny Thomassen AU - Sigbjørn Lien AU - Michael Leaver AU - Jacob S. Torgersen AU - Torgeir R. Hvidsten AU - Jon Olav Vik AU - Simen R. Sandve Y1 - 2017/01/01 UR - http://biorxiv.org/content/early/2017/05/22/140442.abstract N2 - Atlantic salmon migrates from rivers to sea to feed, grow and develop gonads before returning to spawn in freshwater. These habitat shifts require great phenotypic plasticity. To address the unresolved question of how the shift in diet between fresh and saltwater affects the regulation of metabolic function, we fed salmon contrasting diets in each of the two life stages. Combining transcriptomics with comparative genomics, we found that lipid metabolism undergoes a concerted shift between fresh- and saltwater stages. Lipogenesis and lipid transport become less active in liver after transition to saltwater, while genes involved in uptake of dietary lipids in gut greatly increases in lipid-rich seawater environments. We assess how the whole-genome duplication ancestral to salmonids has impacted the evolution of lipid metabolism, and find signatures of pathway-specific selection pressure on gene duplicates and a limited number of cases of increased gene dosage. ER -