RT Journal Article
SR Electronic
T1 Re-evaluating evolution in the HIV reservoir
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 140731
DO 10.1101/140731
A1 Daniel I. S. Rosenbloom
A1 Alison L. Hill
A1 Sarah B. Laskey
A1 Robert F. Siliciano
YR 2017
UL http://biorxiv.org/content/early/2017/05/22/140731.abstract
AB Despite antiretroviral therapy (ART), a latent reservoir of replication-competent HIV-1 persists in resting memory CD4+ T-cells and precludes cure1-6. Lorenzo-Redondo et al.7 analyzed HIV-1 sequences collected from three individuals during the first six months of ART, discovered specific patterns of sequence evolution, and concluded that viral replication persists during therapy. We believe these evolutionary patterns are artifacts of rapidly decaying viral subpopulations present during the first months of therapy and are not characteristic of the long-lived reservoir. The study therefore provides no evidence that ongoing replication is an additional barrier to cure for treated individuals who consistently maintain low viral loads.