RT Journal Article
SR Electronic
T1 Distinct cortical spatial representations learned along disparate visual pathways
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2024.10.10.617687
DO 10.1101/2024.10.10.617687
A1 Lian, Yanbo
A1 LaChance, Patrick A.
A1 Malmberg, Samantha
A1 Hasselmo, Michael E.
A1 Burkitt, Anthony N.
YR 2024
UL http://biorxiv.org/content/early/2024/10/12/2024.10.10.617687.abstract
AB Recent experimental studies have discovered diverse spatial properties, such as head direction tuning and egocentric tuning, of neurons in the postrhinal cortex (POR) and revealed how the POR spatial representation is distinct from the retrosplenial cortex (RSC). However, how these spatial properties of POR neurons emerge is unknown, and the cause of distinct cortical spatial representations is also unclear. Here, we build a learning model of POR based on the pathway from the superior colliculus (SC) that has been shown to have motion processing within the visual input. Our designed SC-POR model demonstrates that diverse spatial properties of POR neurons can emerge from a learning process based on visual input that incorporates motion processing. Moreover, combining SC-POR model with our previously proposed V1-RSC model, we show that distinct cortical spatial representations in POR and RSC can be learnt along disparate visual pathways (originating in SC and V1), suggesting that the varying features encoded in different visual pathways contribute to the distinct spatial properties in downstream cortical areas.Conflict of interest statement The authors declare no competing financial interests.Competing Interest StatementThe authors have declared no competing interest.