RT Journal Article
SR Electronic
T1 Insuperable problems of the genetic code initially emerging in an RNA World
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 140657
DO 10.1101/140657
A1 Peter R Wills
A1 Charles W Carter, Jr
YR 2017
UL http://biorxiv.org/content/early/2017/05/22/140657.abstract
AB Differential equations for error-prone information transfer (template replication, transcription or translation) are developed in order to consider, within the theory of autocatalysis, the advent of coded protein synthesis. Variations of these equations furnish a basis for comparing the plausibility of contrasting scenarios for the emergence of tRNA aminoacylation, ultimately by enzymes, and the relationship of this process with the origin of the universal system of molecular biological information processing embodied in the Central Dogma. The hypothetical RNA World does not furnish an adequate basis for explaining how this system came into being, but principles of self-organisation that transcend Darwinian natural selection furnish an unexpectedly robust basis for a rapid, concerted transition to genetic coding from a peptide•RNA world.