TY - JOUR T1 - A combined use of intravoxel incoherent motion MRI parameters can differentiate early stage hepatitis-b fibrotic livers from healthy livers JF - bioRxiv DO - 10.1101/138958 SP - 138958 AU - Yì Xiáng J. Wáng AU - Min Deng AU - Yáo T. Li AU - Hua Huang AU - Jason Chi Shun Leung AU - Weitian Chen AU - Pu-Xuan Lu Y1 - 2017/01/01 UR - http://biorxiv.org/content/early/2017/05/25/138958.abstract N2 - This study investigated a combined use of IVIM parameters Dslow (D), PF (f) and Dfast (D*) for liver fibrosis evaluation. 16 healthy volunteers (F0) and 33 hepatitis-b patients (stage F1= 15, stage F2-4 = 18) were included. With a 1.5-T MR scanner and respiration-gating, IVIM diffusion weighted imaging was acquired using a single-shot echo-planar imaging sequence with ten b-values of 10, 20, 40, 60, 80, 100, 150, 200, 400, and 800 s/mm2. Signal measurement was performed on right liver parenchyma. With a 3-dimensional tool, Dslow, PF, and Dfast values were placed along the x-axis, y-axis, and z-axis, and a plane was defined to separate healthy volunteers from patients. 3-dimensional tool demonstrated healthy volunteers and all patients with liver fibrosis could be separated. Classification and Regression Tree showed a combination of PF (PF < 12.55%), Dslow (Dslow < 1.152 ×10−3 mm2/s) and Dfast (Dfast <13.36 ×10−3 mm2/s) could differentiate healthy subjects and all fibrotic livers (F1-F4) with an area under the curve of logistic regression (AUC) of 0.986. The AUC for differentiation of healthy livers vs. F2-4 livers was 1. PF offered the best diagnostic value, followed by Dslow; however, all three parameters of PF, Dslow, and Dfast contributed to liver fibrosis detection. ER -