@article {Xiangyuan141515, author = {Yu Xiangyuan and Wang Qianqian and Qin Linyuan and Peng Lingxiang and Chen Zaiming and Qin Xiumei and Wang Yuchun and Shi Qingfeng and Yu Hongping}, title = {Association between a functional polymorphism rs10830963 in melatonin receptor 1B and risk of gestational diabetes mellitus: an updated meta-analysis}, elocation-id = {141515}, year = {2017}, doi = {10.1101/141515}, publisher = {Cold Spring Harbor Laboratory}, abstract = {The melatonin receptor 1B (MTNR1B) as a candidate gene for gestational diabetes mellitus (GDM) on the basis of its association with T2DM, β-cells function and fasting plasma glucose (FPG) level. Many studies have investigated the association between MTNR1B polymorphism rs10830963 C\>G and GDM risk, but the conclusion is inconsistent. PubMed, Google Scholar and CNKI databases were searched to identify eligible studies. Pooled OR with corresponding 95\% CI was used to estimate the strength of the association between rs10830963 and GDM risk using a fixed- or random-effect model. 12 eligible studies with a number of 4,782 GDM patients and 5,605 controls were included in this meta-analysis. Results indicated that the variant G allele of rs10830963 polymorphism was significantly associated with an increased risk of GDM (CG vs. CC: OR=1.23, 95\% CI = 1.12{\textendash}1.34, Pheterogeneity = 0.23; GG vs. CC: OR=1.74, 95\% CI =1.41{\textendash}2.15, Pheterogeneity = 0.002). In the stratified analysis by ethnicity, similar results were found in Asians (CG vs. CC: OR=1.15, 95\% CI = 1.04{\textendash}1.28, Pheterogeneity = 0.74; GG VS. CC: OR=1.48, 95\% CI =1.23{\textendash}1.78, Pheterogeneity = 0.08) and in Caucasians (CG vs. CC: OR=1.49, 95\% CI =1.25{\textendash}1.77, Pheterogeneity = 0.28; GG vs. CC: OR=2.68, 95\% CI =2.03{\textendash}3.54, Pheterogeneity = 0.58).}, URL = {https://www.biorxiv.org/content/early/2017/05/25/141515}, eprint = {https://www.biorxiv.org/content/early/2017/05/25/141515.full.pdf}, journal = {bioRxiv} }