RT Journal Article SR Electronic T1 A neural network model that generates salt concentration memory-dependent chemotaxis in Caenorhabditis elegans JF bioRxiv FD Cold Spring Harbor Laboratory SP 2024.11.04.621960 DO 10.1101/2024.11.04.621960 A1 Hironaka, Masakatsu A1 Sumi, Tomonari YR 2024 UL http://biorxiv.org/content/early/2024/11/05/2024.11.04.621960.abstract AB A neuroanatomical minimal network model was revisited to elucidate the mechanism of salt concentration memory-dependent chemotaxis observed in Caenorhabditis elegans. C. elegans memorizes the salt concentration during cultivation, manifesting a pronounced taste preference for this concentration. The right-side head sensory neuron, designated ASER, exhibits a response to a decrease in salt concentration. The basal level of glutamate transmission from ASER has been demonstrated to transiently increase and decrease when the current environmental salt concentrations are lower and higher, respectively, than that during previous cultivation. Given the sensitivity of excitatory/inhibitory glutamate receptors expressed on the postsynaptic AIY interneurons, it can be anticipated that the ASER-AIY synaptic transmission will undergo a reversal due to alterations in the basal glutamate release. The neural network model, derived with the hypothesis, reproduced the salt concentration memory-dependent preference behavior and revealed the modular neural circuit function downstream of ASE that is responsible for salt klinotaxis.Competing Interest StatementThe authors have declared no competing interest.