RT Journal Article
SR Electronic
T1 Long-lasting, subtype-specific regulation of somatostatin interneurons during sensory learning
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2024.11.19.624383
DO 10.1101/2024.11.19.624383
A1 Zhu, Mo
A1 Mosso, Matthew B.
A1 Ma, Xiaoyang
A1 Park, Eunsol
A1 Barth, Alison L.
YR 2024
UL http://biorxiv.org/content/early/2024/11/21/2024.11.19.624383.abstract
AB Somatostatin (SST)-expressing inhibitory neurons are a major class of neocortical γ-amino butyric acid (GABA) neurons, where morphological, electrophysiological, and transcriptomic analyses indicate more than a dozen different subtypes. However, whether this diversity is related to specific roles in cortical computations and plasticity remains unclear. Here we identify learning-dependent, subtype-specific plasticity in layer 2/3 SST neurons of the mouse somatosensory cortex. Martinotti-type, SST neurons expressing calbindin-2 show a selective decrease in excitatory synaptic input and stimulus-evoked calcium responses as mice learn a stimulus-reward association. Using these insights, we develop a label-free classifier using basal activity from in vivo imaging that accurately predicts learning-associated response plasticity. Our data indicate that molecularly-defined SST neuron subtypes play specific and highly-regulated roles in sensory information processing and learning.Competing Interest StatementThe authors have declared no competing interest.