PT  - JOURNAL ARTICLE
AU  - Timothy G. Vaughan
AU  - Gabriel E. Leventhal
AU  - David A. Rasmussen
AU  - Alexei J. Drummond
AU  - David Welch
AU  - Tanja Stadler
TI  - Directly Estimating Epidemic Curves From Genomic Data
AID  - 10.1101/142570
DP  - 2017 Jan 01
TA  - bioRxiv
PG  - 142570
4099  - http://biorxiv.org/content/early/2017/05/30/142570.short
4100  - http://biorxiv.org/content/early/2017/05/30/142570.full
AB  - Modern phylodynamic methods interpret an inferred phylogenetic tree as a partial transmission chain providing information about the dynamic process of transmission and removal (where removal may be due to recovery, death or behaviour change). Birth-death and coalescent processes have been introduced to model the stochastic dynamics of epidemic spread under common epidemiological models such as the SIS and SIR models, and are successfully used to infer phylogenetic trees together with transmission (birth) and removal (death) rates. These methods integrate analytically over past incidence and prevalence to infer rate parameters, and thus cannot explicitly infer past incidence or prevalence. Here we introduce a particle filtering framework to explicitly infer prevalence and incidence trajectories along with phylogenies and epidemiological model parameters from genomic sequences under the birth-death model. After demonstrating the accuracy of this method on simulated data, we use it to assess the prevalence through time of the early 2014 Ebola outbreak in Sierra Leone.