RT Journal Article
SR Electronic
T1 Anatomical predictors of recovery from visual neglect after prism adaptation therapy
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 144956
DO 10.1101/144956
A1 Marine Lunven
A1 Gilles Rode
A1 Clémence Bourlon
A1 Christophe Duret
A1 Raffaella Migliaccio
A1 Emmanuel Chevrillon
A1 Michel Thiebaut de Schotten
A1 Paolo Bartolomeo
YR 2017
UL http://biorxiv.org/content/early/2017/06/01/144956.abstract
AB Visual neglect is a frequent and disabling consequence of right hemisphere damage. Previous evidence demonstrated a probable role of posterior callosal dysfunction in the chronic persistence of neglect signs. Prism adaptation is a non-invasive and convenient technique to rehabilitate chronic visual neglect, but it is not effective in all patients. Here we hypothesized that prism adaptation improves left neglect by facilitating compensation through the contribution of the left, undamaged hemisphere. To test this hypothesis, we assessed the relationship between prism adaptation effects, cortical thickness and white matter integrity in a group of 14 patients with unilateral right-hemisphere strokes and chronic visual neglect. Consistent with our hypothesis, patients who benefitted from prism adaptation had a thicker cortex in temporo-parietal, prefrontal and cingulate areas of the left, undamaged hemisphere. Additionally, these patients had higher microstructural integrity of the body and genu of the corpus callosum. These callosal regions connect temporo-parietal, sensorimotor and prefrontal areas. Thus, prism adaptation may ameliorate signs of left visual neglect by promoting the contribution of the left hemisphere to neglect compensation. These results support current hypotheses on the role of the healthy hemisphere in the compensation for stroke-induced, chronic neuropsychological deficits, and suggest that prism adaptation can foster this role by exploiting sensorimotor/prefrontal circuits for neglect compensation.HighlightsVisual neglect is a disabling condition resulting from right hemisphere damagePrism adaptation is a promising therapy, but not all patients respondWe assessed the anatomical predictors of patients’ response to prism adaptationStudy of cortical thickness and white matter integrityImportance of fronto-parietal networks in the left, healthy hemisphere for recoveryImportance of callosal connections in the genu and body for recovery