PT - JOURNAL ARTICLE AU - MacArthur, Ben D AU - Greulich, Philip TI - Self-renewal without niche instruction, feedback or fine-tuning AID - 10.1101/2024.12.20.629654 DP - 2025 Jan 01 TA - bioRxiv PG - 2024.12.20.629654 4099 - http://biorxiv.org/content/early/2025/01/09/2024.12.20.629654.short 4100 - http://biorxiv.org/content/early/2025/01/09/2024.12.20.629654.full AB - To self-renew, stem cells must precisely balance proliferation and differentiation. Typically, this is achieved under feedback from the niche; yet many stem cells also possess an intrinsic self-renewal program that allows them to do so autonomously, as required. However, because self-renewal implies a stable equilibrium – in which the expected stem cell number neither increases nor decreases over time – this seems to require fine-tuning to a critical point. Here, we show that this is not the case: self-renewal can, in principle, be easily achieved without the need for extrinsic instruction, feedback or finetuning, by a simple ‘dimerization cycle’ that uses partitioning errors at cell division to reliably establish asymmetric divisions and perfectly balance symmetric divisions.Competing Interest StatementThe authors have declared no competing interest.