RT Journal Article SR Electronic T1 Self-renewal without niche instruction, feedback or fine-tuning JF bioRxiv FD Cold Spring Harbor Laboratory SP 2024.12.20.629654 DO 10.1101/2024.12.20.629654 A1 MacArthur, Ben D A1 Greulich, Philip YR 2025 UL http://biorxiv.org/content/early/2025/01/09/2024.12.20.629654.abstract AB To self-renew, stem cells must precisely balance proliferation and differentiation. Typically, this is achieved under feedback from the niche; yet many stem cells also possess an intrinsic self-renewal program that allows them to do so autonomously, as required. However, because self-renewal implies a stable equilibrium – in which the expected stem cell number neither increases nor decreases over time – this seems to require fine-tuning to a critical point. Here, we show that this is not the case: self-renewal can, in principle, be easily achieved without the need for extrinsic instruction, feedback or finetuning, by a simple ‘dimerization cycle’ that uses partitioning errors at cell division to reliably establish asymmetric divisions and perfectly balance symmetric divisions.Competing Interest StatementThe authors have declared no competing interest.