PT  - JOURNAL ARTICLE
AU  - Sandra Sanchez-Roige
AU  - Pierre Fontanillas
AU  - Sarah L. Elson
AU  - the 23andMe Research Team
AU  - Anita Pandit
AU  - Ellen Schmidt
AU  - Johanna Forster
AU  - Goncalo R. Abecasis
AU  - Joshua C. Gray
AU  - Harriet de Wit
AU  - Lea K. Davis
AU  - James MacKillop
AU  - Abraham A. Palmer
TI  - Genetics of the Research Domain Criteria (RDoC): genome-wide association study of delay discounting
AID  - 10.1101/146936
DP  - 2017 Jan 01
TA  - bioRxiv
PG  - 146936
4099  - http://biorxiv.org/content/early/2017/06/07/146936.short
4100  - http://biorxiv.org/content/early/2017/06/07/146936.full
AB  - Delay discounting (DD), or the tendency to favor immediate over future rewards, is a form of impulsivity that is present in a constellation of diseases. Here we performed a genome-wide association study of DD using 23,127 research participants of European ancestry. We estimated chip heritability at 12%, and identified significant genetic correlations between DD and neuropsychiatric diseases (attention-deficit/hyperactivity disorder (ADHD), schizophrenia, major depression), smoking, personality, cognition, and weight.