PT  - JOURNAL ARTICLE
AU  - Gonzalo Lerner
AU  - Scott Albert
AU  - Pedro A. Caffaro
AU  - Jorge I. Villalta
AU  - Florencia Jacobacci
AU  - Reza Shadmehr
AU  - Valeria Della-Maggiore
TI  - The origins of anterograde interference in visuomotor adaptation
AID  - 10.1101/593996
DP  - 2019 Jan 01
TA  - bioRxiv
PG  - 593996
4099  - http://biorxiv.org/content/early/2019/03/31/593996.short
4100  - http://biorxiv.org/content/early/2019/03/31/593996.full
AB  - Anterograde interference refers to the negative impact of prior learning on the propensity for future learning. Previous work has shown that subsequent adaptation to two perturbations of opposing sign, A and B, impairs performance in B. Here, we aimed to unveil the mechanism at the basis of anterograde interference by tracking its impact as a function of time through a 24h period. We found that the memory of A biased performance in B for all time intervals. Conversely, learning from error was hindered up to 1h following acquisition of A, with release from interference occurring at 6h. These findings suggest that poor performance induced by prior learning is driven by two distinct mechanisms: a long-lasting bias that acts as a prior and hinders the initial level of performance, and a short-lasting learning impairment that originates from a reduction in error-sensitivity. Our work provides insight into the timeline of memory stabilization in visuomotor adaptation.