RT Journal Article
SR Electronic
T1 The origins of anterograde interference in visuomotor adaptation
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 593996
DO 10.1101/593996
A1 Gonzalo Lerner
A1 Scott Albert
A1 Pedro A. Caffaro
A1 Jorge I. Villalta
A1 Florencia Jacobacci
A1 Reza Shadmehr
A1 Valeria Della-Maggiore
YR 2019
UL http://biorxiv.org/content/early/2019/03/31/593996.abstract
AB Anterograde interference refers to the negative impact of prior learning on the propensity for future learning. Previous work has shown that subsequent adaptation to two perturbations of opposing sign, A and B, impairs performance in B. Here, we aimed to unveil the mechanism at the basis of anterograde interference by tracking its impact as a function of time through a 24h period. We found that the memory of A biased performance in B for all time intervals. Conversely, learning from error was hindered up to 1h following acquisition of A, with release from interference occurring at 6h. These findings suggest that poor performance induced by prior learning is driven by two distinct mechanisms: a long-lasting bias that acts as a prior and hinders the initial level of performance, and a short-lasting learning impairment that originates from a reduction in error-sensitivity. Our work provides insight into the timeline of memory stabilization in visuomotor adaptation.