RT Journal Article SR Electronic T1 Multiple conserved cell adhesion protein interactions mediate neural wiring of a sensory circuit in C. elegans JF bioRxiv FD Cold Spring Harbor Laboratory SP 148080 DO 10.1101/148080 A1 Byunghyuk Kim A1 Scott W. Emmons YR 2017 UL http://biorxiv.org/content/early/2017/06/09/148080.abstract AB Nervous system function relies on precise synaptic connections. A number of widely-conserved cell adhesion proteins are implicated in cell recognition between synaptic partners, but how these proteins act as a group to specify a complex neural network is poorly understood. Taking advantage of known connectivity in C. elegans, we identified and studied cell adhesion genes expressed in three interacting neurons in the mating circuits of the adult male. Two interacting pairs of cell surface proteins independently promote fasciculation between sensory neuron HOA and its postsynaptic target interneuron AVG: BAM-2/neurexin-related in HOA binds to CASY-1/calsyntenin in AVG; SAX-7/L1CAM in sensory neuron PHC binds to RIG-6/contactin in AVG. A third, basal pathway results in considerable HOA-AVG fasciculation and synapse formation in the absence of the other two. The features of this multiplexed mechanism help to explain how complex connectivity is encoded and robustly established during nervous system development.