RT Journal Article
SR Electronic
T1 The Healthy Brain Network Biobank: An open resource for transdiagnostic research in pediatric mental health and learning disorders
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 149369
DO 10.1101/149369
A1 Lindsay M. Alexander
A1 Jasmine Escalera
A1 Lei Ai
A1 Charissa Andreotti
A1 Karina Febre
A1 Alexander Mangone
A1 Natan Vega Potler
A1 Nicolas Langer
A1 Alexis Alexander
A1 Meagan Kovacs
A1 Shannon Litke
A1 Bridget O’Hagan
A1 Batya Bronstein
A1 Anastasia Bui
A1 Marijayne Bushey
A1 Victoria Castagna
A1 Nicolas Camacho
A1 Elisha Chan
A1 Danielle Citera
A1 Jon Clucas
A1 Samantha Cohen
A1 Megan Eaves
A1 Brian Fradera
A1 Natalie Grant-Villegas
A1 Gabriella Green
A1 Camille Gregory
A1 Emily Hart
A1 Shana Harris
A1 Catherine Lord
A1 Danielle Kahn
A1 Katya Kabotyanski
A1 Kayla Kleinman
A1 Bonhwang Koo
A1 Eliza Kramer
A1 Amy Margolis
A1 Kathleen R. Merikangas
A1 Judith Milham
A1 Giuseppe Minniti
A1 Rebecca Neuhaus
A1 Alexandra Nussbaum
A1 Yael Osman
A1 Lucas C. Parra
A1 Ken R. Pugh
A1 Amy Racanello
A1 Anita Restrepo
A1 Tian Saltzman
A1 Batya Septimus
A1 Russell Tobe
A1 Rachel Waltz
A1 Anna Williams
A1 Anna Yeo
A1 Francisco X. Castellanos
A1 Arno Klein
A1 Tomas Paus
A1 Bennett L. Leventhal
A1 Cameron R. Craddock
A1 Harold S. Koplewicz
A1 Michael P. Milham
YR 2017
UL http://biorxiv.org/content/early/2017/06/13/149369.abstract
AB Innovations in methods and technologies are equipping researchers with unprecedented capabilities for detecting and characterizing pathologic processes in the developing human brain. As a result, there is growing enthusiasm about the prospect of achieving clinically useful tools that can assist in the diagnosis and management of mental health and learning disorders. For these ambitions to be realized, it is critical to accrue large-scale multimodal datasets that capture a broad range of commonly encountered clinical psychopathology. To this end, the Child Mind Institute has launched the Healthy Brain Network (HBN), an ongoing initiative focused on creating and sharing a biobank comprised of data from 10,000 New York City area children and adolescents (ages 5-21). The HBN has adopted a community-referred recruitment model. Specifically, study advertisements seek the participation of families who have concerns about one or more psychiatric symptoms in their child. The HBN Biobank houses data about psychiatric, behavioral, cognitive, and lifestyle (e.g., fitness, diet) phenotypes, as well as multimodal brain imaging, electroencephalography, digital voice and video recordings, genetics, and actigraphy. In this paper, we present the motivation, rationale and design for the HBN along with the initial implementation and evolution of the HBN protocols. We describe the first major open data release (n = 664) containing descriptive, electroencephalography, and multimodal brain imaging data (resting state and naturalistic viewing functional MRI, diffusion MRI and morphometric MRI). Beyond accelerating transdiagnostic research, we discuss the potential of the HBN Biobank to advance related areas, such as biophysical modeling, voice and speech analysis, natural viewing fMRI and EEG, and methods optimization.LIST OF ABBREVIATIONSABCDAdolescent Brain Cognitive DevelopmentABIDEAutism Brain Imaging Data ExchangeADHDAttention-Deficit/Hyperactivity DisorderADOSAutism Diagnostic Observation ScheduleAROMAAutomatic Removal of Motion ArtifactsBIABioelectrical Impedance AnalysisCELF-5Clinical Evaluation of Language Fundamentals, 5th EditionCMIChild Mind InstituteCOINSCOllaborative Informatics and Neuroimaging SuiteCoRRConsortium for Reliability and ReproducibilityCTOPPComprehensive Test of Phonological ProcessingCUNYCity University of New YorkdMRIdiffusion magnetic resonance imagingDSM-5Diagnostic and Statistical Manual of Mental Disorders, 5th EditionDUAdata usage agreementEEGelectroencephalogramEGIElectrical Geodesics, Inc.EVTExpressive Vocabulary TestFCP1000 Functional Connectomes ProjectfMRIfunctional magnetic resonance imagingFSIQfull scale intelligence quotientGFTAGoldman Fristoe Test of ArticulationHBNHealthy Brain NetworkHIPPAHealth Insurance Portability and Accountability ActIEPIndividualized Education PlanINDIInternational Neuroimaging Data-sharing InitiativeIQintelligence quotientIRBInstitutional Review BoardKBITKaufman Brief Intelligence TestKSADSSchedule for Affective Disorders and Schizophrenia for ChildrenLORISLongitudinal Online Research and Imaging SystemMRImagnetic resonance imagingNIHNational Institutes of HealthNKINathan Kline InstituteNYNew YorkNYCNew York CityPHIprotected health informationPIQperformance intelligence quotientPPVTPeabody Picture Vocabulary TestQAquality assuranceQAPquality assurance planRUBICRutgers University Brain Imaging CenterRVresearch vehicleSMISensoMotoric InstrumentssMRIstructural magnetic resonance imagingTOWRETest of Word Reading EfficiencyVIQverbal intelligence quotientWAIS-IVWechsler Adult Intelligence Scale, 4th EditionWASIWechsler Abbreviated Scale of IntelligenceWIAT-IIIWechsler Individual Achievement Test, 3rd EditionWISC-VWechsler Intelligence Scale for Children, 5th Edition