RT Journal Article
SR Electronic
T1 High levels of antibiotic tolerance and persistence are induced by the commercial anti-microbial triclosan
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 090829
DO 10.1101/090829
A1 Corey S. Westfall
A1 Petra Anne Levin
YR 2017
UL http://biorxiv.org/content/early/2017/06/13/090829.abstract
AB Antimicrobial tolerance and bacterial persistence are confounding factors in the treatment of recurrent and chronic infections. Here we report that the anti-microbial triclosan increased antibiotic tolerance up to 10,000 fold and amplified persister populations in both Escherichia coli and methicillin-resistant Staphylococcus aureus. Triclosan-mediated protection was dependent on the alarmone ppGpp but independent of growth rate, arguing against a simplistic model in which slow growth is sufficient to confer antibiotic tolerance.