PT  - JOURNAL ARTICLE
AU  - Nhan Phan
AU  - Bobby Tofig
AU  - Deanna Janzen
AU  - Jessica Huang
AU  - Sanaz Memarzadeh
AU  - Robert Damoiseaux
AU  - Alice Soragni
TI  - Miniring approach for high-throughput drug screenings in 3D tumor models
AID  - 10.1101/138412
DP  - 2017 Jan 01
TA  - bioRxiv
PG  - 138412
4099  - http://biorxiv.org/content/early/2017/06/28/138412.short
4100  - http://biorxiv.org/content/early/2017/06/28/138412.full
AB  - There is increasing interest in developing 3D tumor organoid models for drug development and personalized medicine approaches. While tumor organoids are in principle amenable to high-throughput drug screenings, progress has been hampered by technical constraints and extensive manipulations required by current approaches. Here, we introduce a miniaturized,fully automatable, flexible high-throughput method using a simplified geometry to establish 3D organoids from cell lines and primary tumors and robustly assay drug responses.