@article {Layer157735, author = {Ryan M. Layer and Brent S. Pedersen and Tonya DiSera and Gabor T. Marth and Jason Gertz and Aaron R. Quinlan}, title = {GIGGLE: a search engine for large-scale integrated genome analysis}, elocation-id = {157735}, year = {2017}, doi = {10.1101/157735}, publisher = {Cold Spring Harbor Laboratory}, abstract = {GIGGLE is a genomics search engine that identifies and ranks the significance of shared genomic loci between query features and thousands of genome interval files. GIGGLE scales to billions of intervals, is faster (+1,000X) than existing methods, and its speed extends the accessibility and utility of resources such as ENCODE, Roadmap Epigenomics, and GTEX by facilitating data integration and hypothesis generation. GIGGLE is available at https://github.com/ryanlayer/giggle.}, URL = {https://www.biorxiv.org/content/early/2017/06/29/157735}, eprint = {https://www.biorxiv.org/content/early/2017/06/29/157735.full.pdf}, journal = {bioRxiv} }