@article {Gehring157859, author = {Tiago V. Gehring and Malgorzata J. Wesierska and Daniel K. W{\'o}jcik and Eleni Vasilaki}, title = {Analysis of behaviour in the Active Allothetic Place Avoidance task based on cluster analysis of the rat movement motifs}, elocation-id = {157859}, year = {2017}, doi = {10.1101/157859}, publisher = {Cold Spring Harbor Laboratory}, abstract = {The Active Allothetic Place Avoidance test (AAPA) is a useful tool to study spatial memory in a dynamic world. In this task a rat, freely moving on a rotating circular arena, has to avoid a sector where shocks are presented. The standard analysis of memory performance in the AAPA task relies on evaluating individual performance measures. Here we present a new method of analysis for the AAPA test that focuses on the movement paths of the animals and utilizes a clustering algorithm to automatically extract the stereotypical types of behaviour as reflected in the recorded paths. We apply the method to experiments that study the effect of silver nanoparticles (AgNPs) on the reference memory and identify six major classes of movement motifs not previously described in AAPA tests. The method allows us to analyse the data with no prior expectations about the motion to be seen in the experiments.}, URL = {https://www.biorxiv.org/content/early/2017/06/30/157859}, eprint = {https://www.biorxiv.org/content/early/2017/06/30/157859.full.pdf}, journal = {bioRxiv} }