PT - JOURNAL ARTICLE AU - Wesley Spiller AU - Neil M. Davies AU - Tom M. Palmer TI - Software Application Profile: mrrobust - a tool for performing two-sample summary Mendelian randomization analyses AID - 10.1101/142125 DP - 2017 Jan 01 TA - bioRxiv PG - 142125 4099 - http://biorxiv.org/content/early/2017/07/05/142125.short 4100 - http://biorxiv.org/content/early/2017/07/05/142125.full AB - Motivation In recent years Mendelian randomization analysis using summary data from genome-wide association studies has become a popular approach for investigating causal relationships in epidemiology. The mrrobust Stata package implements several of the recently developed methods.Implementation mrrobust is freely available as a Stata package.General Features The package includes inverse variance weighted estimation, as well as a range of median and MR-Egger estimation methods. Using mrrobust, plots can be constructed visualising each estimate either individually or simultaneously. The package also provides statistics such as which are useful in assessing attenuation bias in causal estimates.Availability The software is freely available from GitHub [https://raw.github.com/remlapmot/mrrobust/master/].