PT  - JOURNAL ARTICLE
AU  - Stavros I. Dimitriadis
AU  - Christos Salis
AU  - David Linden
TI  - A Novel, Fast and Efficient Single-Sensor Automatic Sleep-Stage Classification Based on Complementary Cross-Frequency Coupling Estimates
AID  - 10.1101/160655
DP  - 2017 Jan 01
TA  - bioRxiv
PG  - 160655
4099  - http://biorxiv.org/content/early/2017/07/07/160655.short
4100  - http://biorxiv.org/content/early/2017/07/07/160655.full
AB  - Objective Limitations of the manual scoring of polysomnograms, which include data from electroencephalogram (EEG), electrooculogram (EOG), electrocardiogram (ECG) and electromyogram (EMG) channels, have long been recognised. Manual staging is resource-intensive and time-consuming and considerable efforts have to be spent to ensure inter-rater reliability. There is thus great interest in techniques based on signal processing and machine learning for a completely Automatic Sleep Stage Classification (ASSC).Methods In this paper, we present a single EEG-sensor ASSC technique based on dynamic reconfiguration of different aspects of cross-frequency coupling (CFC) estimated between predefined frequency pairs over 5s epoch lengths. The proposed analytic scheme is demonstrated using the PhysioNet Sleep European Data Format (EDF) Database using 20 healthy young adults with repeat recordings.Results We achieved very high classification sensitivity, specificity and accuracy of 96.2 ± 2.2%, 94.2 ± 2.3%, and 94.4 ± 2.2% across 20 folds, respectively and high mean F1-score (92%, range 90–94%) when multi-class Bayes Naive classifier was applied.Conclusions Our method outperformed the accuracy of previous studies on different datasets but also on the same database.Significance Single-sensor ASSC makes the whole methodology appropriate for longitudinal monitoring using wearable EEG in real world and lab-oriented environments.