RT Journal Article
SR Electronic
T1 Brain xQTL map: Integrating the genetic architecture of the human brain transcriptome and epigenome
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 142927
DO 10.1101/142927
A1 B Ng
A1 CC White
A1 H Klein
A1 SK Sieberts
A1 C McCabe
A1 E Patrick
A1 J Xu
A1 L Yu
A1 C Gaiteri
A1 DA Bennett
A1 S Mostafavi
A1 De Jager PL
YR 2017
UL http://biorxiv.org/content/early/2017/07/07/142927.abstract
AB We perform quantitative trait locus (xQTL) analyses on a multi-omic dataset, comprising RNA sequence, DNA methylation, and histone acetylation ChIP sequence data from the dorsolateral prefrontal cortex of 411 older adult individuals. We identify SNPs that are significantly associated with gene expression, DNA methylation, and histone modification levels. Many SNPs influence more than one type of molecular feature, and epigenetic features are shown to mediate eQTLs in a number of (9%) such loci. We illustrate the utility of our new resource, xQTL Serve, in prioritizing the cell type most affected by an xQTL and in enhancing genome wide association studies (GWAS) as we report 18 additional CNS disease susceptibility loci after re-analyzing published studies.