RT Journal Article
SR Electronic
T1 Pan-cancer analysis of whole genomes
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 162784
DO 10.1101/162784
A1 Peter J Campbell
A1 Gaddy Getz
A1 Joshua M Stuart
A1 Jan O Korbel
A1 Lincoln D Stein
A1 ,
YR 2017
UL http://biorxiv.org/content/early/2017/07/12/162784.abstract
AB We report the integrative analysis of more than 2,600 whole cancer genomes and their matching normal tissues across 39 distinct tumour types. By studying whole genomes we have been able to catalogue non-coding cancer driver events, study patterns of structural variation, infer tumour evolution, probe the interactions among variants in the germline genome, the tumour genome and the transcriptome, and derive an understanding of how coding and non-coding variations together contribute to driving individual patient's tumours. This work represents the most comprehensive look at cancer whole genomes to date. NOTE TO READERS: This is an incomplete draft of the marker paper for the Pan-Cancer Analysis of Whole Genomes Project, and is intended to provide the background information for a series of in-depth papers that will be posted to BioRixv during the summer of 2017.