RT Journal Article SR Electronic T1 The amount of nitrogen used for photosynthesis governs molecular evolution in plants JF bioRxiv FD Cold Spring Harbor Laboratory SP 162693 DO 10.1101/162693 A1 Steven Kelly YR 2017 UL http://biorxiv.org/content/early/2017/07/13/162693.abstract AB Genome and transcript sequences are composed of long strings of nucleotide monomers (A, C, G and T/U) that require different quantities of nitrogen atoms for biosynthesis. Here it is shown that plants that require more nitrogen for photosynthesis use nucleotides with fewer nitrogen atoms in both genome and transcript sequences. These findings reveal that plant GC content, codon use, and gene sequence evolution are driven by photosynthetic nitrogen demand.