PT  - JOURNAL ARTICLE
AU  - Rivera, César
AU  - de Oliveira, Ana Karina
AU  - Pereira e Costa, Rute Alves
AU  - Rossi, Tatiane De
AU  - Paes Leme, Adriana Franco
TI  - Prognostic biomarkers in oral squamous cell carcinoma: a systematic review
AID  - 10.1101/164111
DP  - 2017 Jan 01
TA  - bioRxiv
PG  - 164111
4099  - http://biorxiv.org/content/early/2017/07/16/164111.short
4100  - http://biorxiv.org/content/early/2017/07/16/164111.full
AB  - Over the years, several tumor biomarkers have been suggested to foresee the prognosis of oral squamous cell carcinoma (OSCC) patients. Here, we present a systematic review to identify, evaluate and summarize the evidence for OSCC reported markers. Eligible studies were identified through a literature search of MEDLINE/PubMed until January 2016. We included primary articles reporting overall survival, disease-free survival and cause-specific survival as outcomes. Our findings were analysed using REporting recommendations for tumor MARKer prognostic studies (REMARK), QuickGo tool and SciCurve trends. We found 41 biomarkers, mostly proteins evaluated by immunohistochemistry. The selected studies are of good quality, although, any study referred to a sample size determination. Considering the lack of follow-up studies, the molecules are still potential biomarkers. Further research is required to validate these biomarkers in well-designed clinical cohort-based studies.