RT Journal Article
SR Electronic
T1 Prognostic biomarkers in oral squamous cell carcinoma: a systematic review
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 164111
DO 10.1101/164111
A1 Rivera, César
A1 de Oliveira, Ana Karina
A1 Pereira e Costa, Rute Alves
A1 Rossi, Tatiane De
A1 Paes Leme, Adriana Franco
YR 2017
UL http://biorxiv.org/content/early/2017/07/16/164111.abstract
AB Over the years, several tumor biomarkers have been suggested to foresee the prognosis of oral squamous cell carcinoma (OSCC) patients. Here, we present a systematic review to identify, evaluate and summarize the evidence for OSCC reported markers. Eligible studies were identified through a literature search of MEDLINE/PubMed until January 2016. We included primary articles reporting overall survival, disease-free survival and cause-specific survival as outcomes. Our findings were analysed using REporting recommendations for tumor MARKer prognostic studies (REMARK), QuickGo tool and SciCurve trends. We found 41 biomarkers, mostly proteins evaluated by immunohistochemistry. The selected studies are of good quality, although, any study referred to a sample size determination. Considering the lack of follow-up studies, the molecules are still potential biomarkers. Further research is required to validate these biomarkers in well-designed clinical cohort-based studies.