@article {Schaefer135632, author = {Alexander Schaefer and Ru Kong and Evan M. Gordon and Timothy O. Laumann and Xi-Nian Zuo and Avram J. Holmes and Simon B. Eickhoff and B. T. Thomas Yeo}, title = {Local-Global Parcellation of the Human Cerebral Cortex From Intrinsic Functional Connectivity MRI}, elocation-id = {135632}, year = {2017}, doi = {10.1101/135632}, publisher = {Cold Spring Harbor Laboratory}, abstract = {A central goal in systems neuroscience is the parcellation of the cerebral cortex into discrete neurobiological {\textquotedblleft}atoms{\textquotedblright}. Resting-state functional magnetic resonance imaging (rs-fMRI) offers the possibility of in-vivo human cortical parcellation. Almost all previous parcellations relied on one of two approaches. The local gradient approach detects abrupt transitions in functional connectivity patterns. These transitions potentially reflect cortical areal boundaries defined by histology or visuotopic fMRI. By contrast, the global similarity approach clusters similar functional connectivity patterns regardless of spatial proximity, resulting in parcels with homogeneous (similar) rs-fMRI signals. Here we propose a gradient-weighted Markov Random Field (gwMRF) model integrating local gradient and global similarity approaches. Using task-fMRI and rs-fMRI across diverse acquisition protocols, we found gwMRF parcellations to be more homogeneous than four previously published parcellations. Furthermore, gwMRF parcellations agreed with the boundaries of certain cortical areas defined using histology and visuotopic fMRI. Some parcels captured sub-areal (somatotopic and visuotopic) features that likely reflect distinct computational units within known cortical areas. These results suggest that gwMRF parcellations reveal neurobiologically meaningful features of brain organization and are potentially useful for future applications requiring dimensionality reduction of voxel-wise fMRI data. Multi-resolution parcellations generated from 1489 participants are available (https://github.com/ThomasYeoLab/CBIG/tree/master/stable_projects/brain_parcellation/Schaefer2018_LocalGlobal)}, URL = {https://www.biorxiv.org/content/early/2017/07/16/135632}, eprint = {https://www.biorxiv.org/content/early/2017/07/16/135632.full.pdf}, journal = {bioRxiv} }