TY - JOUR T1 - An open resource for transdiagnostic research in pediatric mental health and learning disorders JF - bioRxiv DO - 10.1101/149369 SP - 149369 AU - Lindsay M. Alexander AU - Jasmine Escalera AU - Lei Ai AU - Charissa Andreotti AU - Karina Febre AU - Alexander Mangone AU - Natan Vega Potler AU - Nicolas Langer AU - Alexis Alexander AU - Meagan Kovacs AU - Shannon Litke AU - Bridget O’Hagan AU - Jennifer Andersen AU - Batya Bronstein AU - Anastasia Bui AU - Marijayne Bushey AU - Henry Butler AU - Victoria Castagna AU - Nicolas Camacho AU - Elisha Chan AU - Danielle Citera AU - Jon Clucas AU - Samantha Cohen AU - Sarah Dufek AU - Megan Eaves AU - Brian Fradera AU - Judith Gardner AU - Natalie Grant-Villegas AU - Gabriella Green AU - Camille Gregory AU - Emily Hart AU - Shana Harris AU - Megan Horton AU - Danielle Kahn AU - Katherine Kabotyanski AU - Bernard Karmel AU - Simon P. Kelly AU - Kayla Kleinman AU - Bonhwang Koo AU - Eliza Kramer AU - Elizabeth Lennon AU - Catherine Lord AU - Ginny Mantello AU - Amy Margolis AU - Kathleen R. Merikangas AU - Judith Milham AU - Giuseppe Minniti AU - Rebecca Neuhaus AU - Alexandra Nussbaum AU - Yael Osman AU - Lucas C. Parra AU - Ken R. Pugh AU - Amy Racanello AU - Anita Restrepo AU - Tian Saltzman AU - Batya Septimus AU - Russell Tobe AU - Rachel Waltz AU - Anna Williams AU - Anna Yeo AU - Francisco X. Castellanos AU - Arno Klein AU - Tomas Paus AU - Bennett L. Leventhal AU - R. Cameron Craddock AU - Harold S. Koplewicz AU - Michael P. Milham Y1 - 2017/01/01 UR - http://biorxiv.org/content/early/2017/07/17/149369.abstract N2 - Technological and methodological innovations are equipping researchers with unprecedented capabilities for detecting and characterizing pathologic processes in the developing human brain. As a result, ambitions to achieve clinically useful tools to assist in the diagnosis and management of mental health and learning disorders are gaining momentum. To this end, it is critical to accrue large-scale multimodal datasets that capture a broad range of commonly encountered clinical psychopathology. The Child Mind Institute has launched the Healthy Brain Network (HBN), an ongoing initiative focused on creating and sharing a biobank of data from 10,000 New York area participants (ages 5-21). The HBN Biobank houses data about psychiatric, behavioral, cognitive, and lifestyle phenotypes, as well as multimodal brain imaging (resting and naturalistic viewing fMRI, diffusion MRI, morphometric MRI), electroencephalography, eye-tracking, voice and video recordings, genetics, and actigraphy. Here, we present the rationale, design and implementation of HBN protocols. We describe the first data release (n = 664) and the potential of the biobank to advance related areas (e.g., biophysical modeling, voice analysis).LIST OF ABBREVIATIONSABCDAdolescent Brain Cognitive DevelopmentABIDEAutism Brain Imaging Data ExchangeADHDAttention-Deficit/Hyperactivity DisorderADOSAutism Diagnostic Observation ScheduleAROMAAutomatic Removal of Motion ArtifactsBIABioelectrical Impedance AnalysisCELF-5Clinical Evaluation of Language Fundamentals, 5th EditionCMIChild Mind InstituteCOINSCOllaborative Informatics and Neuroimaging SuiteCoRRConsortium for Reliability and ReproducibilityCTOPPComprehensive Test of Phonological ProcessingCUNYCity University of New YorkdMRIdiffusion magnetic resonance imagingDSM-5Diagnostic and Statistical Manual of Mental Disorders, 5th EditionDUAdata usage agreementEEGelectroencephalogramEGIElectrical Geodesics, Inc.EVTExpressive Vocabulary TestFCP1000 Functional Connectomes ProjectfMRIfunctional magnetic resonance imagingFSIQfull scale intelligence quotientGFTAGoldman Fristoe Test of ArticulationHBNHealthy Brain NetworkHIPAAHealth Insurance Portability and Accountability ActIEPIndividualized Education PlanINDIInternational Neuroimaging Data-sharing InitiativeIQintelligence quotientIRBInstitutional Review BoardKBITKaufman Brief Intelligence TestKSADSSchedule for Affective Disorders and Schizophrenia for ChildrenLORISLongitudinal Online Research and Imaging SystemMRImagnetic resonance imagingNIHNational Institutes of HealthNKINathan Kline InstituteNYNew YorkNYCNew York CityPHIprotected health informationPIQperformance intelligence quotientPPVTPeabody Picture Vocabulary TestQAquality assuranceQAPquality assurance planRUBICRutgers University Brain Imaging CenterRVresearch vehicleSMISensoMotoric Instruments sMRI: structural magnetic resonance imagingTOWRETest of Word Reading EfficiencyVIQverbal intelligence quotientWAIS-IVWechsler Adult Intelligence Scale, 4th EditionWASIWechsler Abbreviated Scale of IntelligenceWIAT-IIIWechsler Individual Achievement Test, 3rd EditionWISC-VWechsler Intelligence Scale for Children, 5th Edition ER -