TY - JOUR T1 - Connectome-harmonic decomposition of human brain activity reveals dynamical repertoire re-organization under LSD JF - bioRxiv DO - 10.1101/163667 SP - 163667 AU - Selen Atasoy AU - Leor Roseman AU - Mendel Kaelen AU - Morten L. Kringelbach AU - Gustavo Deco AU - Robin Carhart-Harris Y1 - 2017/01/01 UR - http://biorxiv.org/content/early/2017/07/19/163667.abstract N2 - Recent studies have started to elucidate the effects of lysergic acid diethylamide (LSD) on the human brain but the underlying dynamics are not yet fully understood. Here we used ‘connectome-harmonic decomposition’, a novel method to investigate the dynamical changes in brain states. We found that LSD alters the energy and the power of individual harmonic brain states in a frequency-selective manner. Remarkably, this leads to an expansion of the repertoire of active brain states, suggestive of a general re-organization of brain dynamics given the non-random increase in co-activation across frequencies. Interestingly, the frequency distribution of the active repertoire of brain states under LSD closely follows power-laws indicating a re-organization of the dynamics at the edge of criticality. Beyond the present findings, these methods open up for a better understanding of the complex brain dynamics in health and disease.HighlightsIntroducing a novel connectome-harmonic decomposition of human brain activity, which is used to study the dynamics after administration of lysergic acid diethylamide (LSD)LSD alters the total energy and power of individual harmonics in a frequency-selective manner and increases the size of the dynamical repertoire of these brain statesThe repertoire expansion occurs in a non-random fashion suggesting a re-organization of brain dynamics at the edge of criticality ER -