RT Journal Article SR Electronic T1 Within-finger maps of tactile and nociceptive input in the human parietal cortex JF bioRxiv FD Cold Spring Harbor Laboratory SP 599167 DO 10.1101/599167 A1 Mancini, Flavia A1 Sereno, Martin I. A1 Lee, Min-Ho A1 Iannetti, Giandomenico D A1 Tracey, Irene YR 2019 UL http://biorxiv.org/content/early/2019/04/04/599167.abstract AB The spatial representation of nociceptive input in the human parietal cortex is not fully understood. For instance, it is known that the primary somatosensory cortex (S1) contains a representation of nociceptive-selective input to different fingers, but it is unclear whether S1 subdivisions contain finer-grained, within-finger maps of nociceptive input. It is also unknown whether within-finger maps of somatosensory input exist in intraparietal regions. Therefore, we used high-field 7T functional MRI to reveal within-finger maps of nociceptive and tactile inputs in the human parietal cortex. Although we replicated the previous findings of between-finger maps of nociceptive input spanning S1 subdivisions, we found weak and inconsistent evidence for within-finger maps of nociceptive input in S1 subdivisions. In the same subjects, we found mirrored, within-finger maps of tactile input in areas 3a, 3b, and 1. Importantly, we discovered a within-finger map of nociceptive input, but not of tactile input, in the human intraparietal area 1 (hIP1). In conclusion, our study indicates that the spatial representation of nociceptive input in the parietal cortex partly differs from that of tactile input and reports the discovery of a within-finger map of nociceptive input in hIP1.New & Noteworthy We report the discovery of a fine-grained map of nociceptive input to finger segments in the human intraparietal area 1.