RT Journal Article
SR Electronic
T1 Low rate of somatic mutations in a long-lived oak tree
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 149203
DO 10.1101/149203
A1 Namrata Sarkar
A1 Emanuel Schmid-Siegert
A1 Christian Iseli
A1 Sandra Calderon
A1 Caroline Gouhier-Darimont
A1 Jacqueline Chrast
A1 Pietro Cattaneo
A1 Frédéric Schütz
A1 Laurent Farinelli
A1 Marco Pagni
A1 Michel Schneider
A1 Jérémie Voumard
A1 Michel Jaboyedoff
A1 Christian Fankhauser
A1 Christian S. Hardtke
A1 Laurent Keller
A1 John R. Pannell
A1 Alexandre Reymond
A1 Marc Robinson-Rechavi
A1 Ioannis Xenarios
A1 Philippe Reymond
YR 2017
UL http://biorxiv.org/content/early/2017/07/24/149203.abstract
AB Because plants do not possess a proper germline, deleterious somatic mutations can be passed to gametes and a large number of cell divisions separating zygote from gamete formation in long-lived plants may lead to many mutations. We sequenced the genome of two terminal branches of a 234-year-old oak tree and found few fixed somatic single-nucleotide variants (SNVs), whose sequential appearance in the tree could be traced along nested sectors of younger branches. Our data suggest that stem cells of shoot meristems are robustly protected from accumulation of mutations in trees.