RT Journal Article
SR Electronic
T1 Catecholaminergic Manipulation Alters Dynamic Network Topology Across Behavioral States
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 169102
DO 10.1101/169102
A1 James M. Shine
A1 Ruud L. van den Brink
A1 Dennis Hernaus
A1 Sander Nieuwenhuis
A1 Russell A. Poldrack
YR 2017
UL http://biorxiv.org/content/early/2017/07/27/169102.abstract
AB The human brain is able to flexibly adapt its information processing capacity to meet a variety of cognitive challenges. Recent evidence suggests that this flexibility is reflected in the dynamic reorganization of the functional connectome. The ascending catecholaminergic arousal systems of the brain are a plausible candidate mechanism for driving alterations in network architecture, enabling efficient deployment of cognitive resources when the environment demands them. We tested this hypothesis by analyzing both task-free and task-based fMRI data following the administration of atomoxetine, a noradrenaline reuptake inhibitor, compared to placebo, in two separate human fMRI studies. Our results demonstrate that the manipulation of central catecholamine levels leads to a reorganization of the functional connectome in a manner that is sensitive to ongoing cognitive demands.