RT Journal Article
SR Electronic
T1 Altered expression of a unique set of genes reveals complex etiology of Schizophrenia
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 131623
DO 10.1101/131623
A1 Ashutosh Kumar
A1 Himanshu Narayan Singh
A1 Vikas Pareek
A1 Khursheed Raza
A1 Pavan Kumar
A1 Muneeb A. Faiq
A1 Sankat Mochan
A1 Subrahamanyam Dantham
A1 Ashish Datt Upadhyaya
YR 2017
UL http://biorxiv.org/content/early/2017/07/28/131623.abstract
AB Purpose The etiology of schizophrenia is extensively debated, and multiple factors have been contended to be involved. A panoramic view of the contributing factors in a genome-wide study can be an effective strategy to provide a comprehensive understanding of its causality.Materials and Methods GSE53987 dataset downloaded from GEO-database, which comprised mRNA expression data of post-mortem brain tissue across three regions from control and age-matched subjects of schizophrenia (N= Hippocampus (HIP): C-15, T-18, Prefrontal cortex (PFC): C-15, T-19, Associative striatum (STR): C-18, T-18). Bio-conductor-affy-package used to compute mRNA expression, and further t-test applied to investigate differential gene expression. The analysis of the derived genes performed using PANTHER Classification System and NCBI database.Results A set of 40 genes showed significantly altered (p<0.01) expression across all three brain regions. The analyses unraveled genes implicated in biological processes and events, and molecular pathways relating basic neuronal functions.Conclusions The deviant expression of genes maintaining basic cell machinery explains compromised neuronal processing in SCZ.Abbreviations Schizophrenia (SCZ), Hippocampus (HIP), Associative striatum (STR), Prefrontal cortex (PFC)