TY - JOUR T1 - Opposing spatial gradients of inhibition and neural activity in mouse olfactory cortex JF - bioRxiv DO - 10.1101/152975 SP - 152975 AU - Adam M. Large AU - Nathan W. Vogler AU - Martha Canto-Bustos AU - Paul Schick AU - Anne-Marie M. Oswald Y1 - 2017/01/01 UR - http://biorxiv.org/content/early/2017/07/31/152975.abstract N2 - The spatial representation of stimuli in primary sensory cortices is a convenient scaffold for elucidating the circuit mechanisms underlying sensory processing. In contrast, the anterior piriform cortex (APC) lacks topology for odor identity and appears homogenous in terms of afferent and intracortical excitatory circuitry. Here, we show that an increasing rostral-caudal (RC) gradient of inhibition onto pyramidal cells is commensurate with a decrease in active neurons along the RC axis following exploration of a novel odor environment. This inhibitory gradient is supported by somatostatin interneurons that provide an opposing, rostrally-biased, gradient of inhibition to interneurons. Optogenetic or chemogenetic modulation of somatostatin cells neutralizes the inhibitory gradient onto pyramidal cells. This suggests a novel circuit mechanism whereby opposing spatial gradients of inhibition and disinhibition regulate neural activity along the RC-axis. These findings challenge our current understanding of the spatial profiles of neural circuits and odor processing within APC. ER -