RT Journal Article
SR Electronic
T1 Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 173435
DO 10.1101/173435
A1 Douglas M Ruderfer
A1 Stephan Ripke
A1 Andrew McQuillin
A1 James Boocock
A1 Eli A Stahl
A1 Jennifer M Whitehead Pavlides
A1 Niamh Mullins
A1 Alexander W Charney
A1 Anil P S Ori
A1 Loes M Olde Loohuis
A1 Enrico Domenici
A1 Arianna Di Florio
A1 Sergi Papiol
A1 Janos L. Kalman
A1 Rolf Adolfsson
A1 Ingrid Agartz
A1 Esben Agerbo
A1 Huda Akil
A1 Diego Albani
A1 Margot Albus
A1 Martin Alda
A1 Madeline Alexander
A1 Judith Allardyce
A1 Ney Alliey-Rodriguez
A1 Thomas D Als
A1 Farooq Amin
A1 Adebayo Anjorin
A1 Maria J Arranz
A1 Swapnil Awasthi
A1 Silviu A Bacanu
A1 Judith A Badner
A1 Marie Baekvad-Hansen
A1 Steven Bakker
A1 Gavin Band
A1 Jack D Barchas
A1 Ines Barroso
A1 Nicholas Bass
A1 Michael Bauer
A1 Bernhard T Baune
A1 Martin Begemann
A1 Celine Bellenguez
A1 Richard A Belliveau, Jr
A1 Frank Bellivier
A1 Stephan Bender
A1 Judit Bene
A1 Sarah E Bergen
A1 Wade H Berrettini
A1 Elizabeth Bevilacqua
A1 Joanna M Biernacka
A1 Tim B Bigdeli
A1 Donald W Black
A1 Hannah Blackburn
A1 Jenefer M Blackwell
A1 Douglas HR Blackwood
A1 Carsten Bocker Pedersen
A1 Michael Boehnke
A1 Marco Boks
A1 Anders D Borglum
A1 Elvira Bramon
A1 Gerome Breen
A1 Matthew A Brown
A1 Richard Bruggeman
A1 Nancy G Buccola
A1 Randy L Buckner
A1 Monika Budde
A1 Brendan Bulik-Sullivan
A1 Suzannah J Bumpstead
A1 William Bunney
A1 Margit Burmeister
A1 Joseph D Buxbaum
A1 Jonas Bybjerg-Grauholm
A1 William Byerley
A1 Wiepke Cahn
A1 Guiqing Cai
A1 Murray J Cairns
A1 Dominique Campion
A1 Rita M Cantor
A1 Vaughan J Carr
A1 Noa Carrera
A1 Juan P Casas
A1 Miquel Casas
A1 Stanley V Catts
A1 Pablo Cervantes
A1 Kimberley D Chambert
A1 Raymond CK Chan
A1 Eric YH Chen
A1 Ronald YL Chen
A1 Wei Cheng
A1 Eric FC Cheung
A1 Siow Ann Chong
A1 Toni-Kim Clarke
A1 C Robert Cloninger
A1 David Cohen
A1 Nadine Cohen
A1 Jonathan R I Coleman
A1 David A Collier
A1 Paul Cormican
A1 William Coryell
A1 Nicholas Craddock
A1 David W Craig
A1 Benedicto Crespo-Facorro
A1 James J Crowley
A1 Cristiana Cruceanu
A1 David Curtis
A1 Piotr M Czerski
A1 Anders M Dale
A1 Mark J Daly
A1 Udo Dannlowski
A1 Ariel Darvasi
A1 Michael Davidson
A1 Kenneth L Davis
A1 Christiaan A de Leeuw
A1 Franziska Degenhardt
A1 Jurgen Del Favero
A1 Lynn E DeLisi
A1 Panos Deloukas
A1 Ditte Demontis
A1 J Raymond DePaulo
A1 Marta di Forti
A1 Dimitris Dikeos
A1 Timothy Dinan
A1 Srdjan Djurovic
A1 Amanda L Dobbyn
A1 Peter Donnelly
A1 Gary Donohoe
A1 Elodie Drapeau
A1 Serge Dronov
A1 Jubao Duan
A1 Frank Dudbridge
A1 Audrey Duncanson
A1 Howard Edenberg
A1 Sarah Edkins
A1 Hannelore Ehrenreich
A1 Peter Eichhammer
A1 Torbjorn Elvsashagen
A1 Johan Eriksson
A1 Valentina Escott-Price
A1 Tonu Esko
A1 Laurent Essioux
A1 Bruno Etain
A1 Chun Chieh Fan
A1 Kai-How Farh
A1 Martilias S Farrell
A1 Matthew Flickinger
A1 Tatiana M Foroud
A1 Liz Forty
A1 Josef Frank
A1 Lude Franke
A1 Christine Fraser
A1 Robert Freedman
A1 Colin Freeman
A1 Nelson B Freimer
A1 Joseph I Friedman
A1 Menachem Fromer
A1 Mark A Frye
A1 Janice M Fullerton
A1 Katrin Gade
A1 Julie Garnham
A1 Helena A Gaspar
A1 Pablo V Gejman
A1 Giulio Genovese
A1 Lyudmila Georgieva
A1 Claudia Giambartolomei
A1 Eleni Giannoulatou
A1 Ina Giegling
A1 Michael Gill
A1 Matthew Gillman
A1 Marianne Giortz Pedersen
A1 Paola Giusti-Rodriguez
A1 Stephanie Godard
A1 Fernando Goes
A1 Jacqueline I Goldstein
A1 Srihari Gopal
A1 Scott D Gordon
A1 Katherine Gordon-Smith
A1 Jacob Gratten
A1 Emma Gray
A1 Elaine K Green
A1 Melissa J Green
A1 Tiffany A Greenwood
A1 Maria Grigoroiu-Serbanescu
A1 Jakob Grove
A1 Weihua Guan
A1 Hugh Gurling
A1 Jose Guzman Parra
A1 Rhian Gwilliam
A1 Lieuwe de Haan
A1 Jeremy Hall
A1 Mei-Hua Hall
A1 Christian Hammer
A1 Naomi Hammond
A1 Marian L Hamshere
A1 Mark Hansen
A1 Thomas Hansen
A1 Vahram Haroutunian
A1 Annette M Hartmann
A1 Joanna Hauser
A1 Martin Hautzinger
A1 Urs Heilbronner
A1 Garrett Hellenthal
A1 Frans A Henskens
A1 Stefan Herms
A1 Maria Hipolito
A1 Joel N Hirschhorn
A1 Per Hoffmann
A1 Mads V Hollegaard
A1 David M Hougaard
A1 Hailiang Huang
A1 Laura Huckins
A1 Christina M Hultman
A1 Sarah E Hunt
A1 Masashi Ikeda
A1 Nakao Iwata
A1 Conrad Iyegbe
A1 Assen V Jablensky
A1 Stephane Jamain
A1 Janusz Jankowski
A1 Alagurevathi Jayakumar
A1 Inge Joa
A1 Ian Jones
A1 Lisa A Jones
A1 Erik G Jonsson
A1 Antonio Julia
A1 Anders Jureus
A1 Anna K Kahler
A1 Rene S Kahn
A1 Luba Kalaydjieva
A1 Radhika Kandaswamy
A1 Sena Karachanak-Yankova
A1 Juha Karjalainen
A1 Robert Karlsson
A1 David Kavanagh
A1 Matthew C Keller
A1 Brian J Kelly
A1 John Kelsoe
A1 James L Kennedy
A1 Andrey Khrunin
A1 Yunjung Kim
A1 George Kirov
A1 Sarah Kittel-Schneider
A1 Janis Klovins
A1 Jo Knight
A1 Sarah V Knott
A1 James A Knowles
A1 Manolis Kogevinas
A1 Bettina Konte
A1 Eugenia Kravariti
A1 Vaidutis Kucinskas
A1 Zita Ausrele Kucinskiene
A1 Ralph Kupka
A1 Hana Kuzelova-Ptackova
A1 Mikael Landen
A1 Cordelia Langford
A1 Claudine Laurent
A1 Jacob Lawrence
A1 Stephen Lawrie
A1 William B Lawson
A1 Markus Leber
A1 Marion Leboyer
A1 Phil H Lee
A1 Jimmy Lee Chee Keong
A1 Sophie E Legge
A1 Todd Lencz
A1 Bernard Lerer
A1 Douglas F Levinson
A1 Shawn E Levy
A1 Cathryn M Lewis
A1 Jun Z Li
A1 Miaoxin Li
A1 Qingqin S Li
A1 Tao Li
A1 Kung-Yee Liang
A1 Jennifer Liddle
A1 Jeffrey Lieberman
A1 Svetlana Limborska
A1 Kuang Lin
A1 Don H Linszen
A1 Jolanta Lissowska
A1 Chunyu Liu
A1 Jianjun Liu
A1 Jouko Lonnqvist
A1 Carmel M Loughland
A1 Jan Lubinski
A1 Susanne Lucae
A1 Milan Macek, Jr
A1 Donald J MacIntyre
A1 Patrik KE Magnusson
A1 Brion S Maher
A1 Pamela B Mahon
A1 Wolfgang Maier
A1 Anil K Malhotra
A1 Jacques Mallet
A1 Ulrik F Malt
A1 Hugh S Markus
A1 Sara Marsal
A1 Nicholas G Martin
A1 Ignacio Mata
A1 Christopher G Mathew
A1 Manuel Mattheisen
A1 Morten Mattingsdal
A1 Fermin Mayoral
A1 Owen T McCann
A1 Robert W McCarley
A1 Steven A McCarroll
A1 Mark I McCarthy
A1 Colm McDonald
A1 Susan L McElroy
A1 Peter McGuffin
A1 Melvin G Mclnnis
A1 Andrew M McIntosh
A1 James D McKay
A1 Francis J McMahon
A1 Helena Medeiros
A1 Sarah E Medland
A1 Sandra Meier
A1 Carin J Meijer
A1 Bela Melegh
A1 Ingrid Melle
A1 Fan Meng
A1 Raquelle I Mesholam-Gately
A1 Andres Metspalu
A1 Patricia T Michie
A1 Lili Milani
A1 Vihra Milanova
A1 Philip B Mitchell
A1 Younes Mokrab
A1 Grant W Montgomery
A1 Jennifer L Moran
A1 Gunnar Morken
A1 Derek W Morris
A1 Ole Mors
A1 Preben B Mortensen
A1 Bryan J Mowry
A1 Thomas W Mühleisen
A1 Bertram Müller-Myhsok
A1 Kieran C Murphy
A1 Robin M Murray
A1 Richard M Myers
A1 Inez Myin-Germeys
A1 Benjamin M Neale
A1 Mari Nelis
A1 Igor Nenadic
A1 Deborah A Nertney
A1 Gerald Nestadt
A1 Kristin K Nicodemus
A1 Caroline M Nievergelt
A1 Liene Nikitina-Zake
A1 Vishwajit Nimgaonkar
A1 Laura Nisenbaum
A1 Merete Nordentoft
A1 Annelie Nordin
A1 Markus M Nöthen
A1 Evaristus A Nwulia
A1 Eadbhard O’Callaghan
A1 Claire O’Donovan
A1 O’Dushlaine Colm
A1 F Anthony O’Neill
A1 Ketil J Oedegaard
A1 Sang-Yun Oh
A1 Ann Olincy
A1 Line Olsen
A1 Lilijana Oruc
A1 Jim Van Os
A1 Michael J Owen
A1 Sara A Paciga
A1 Colin N A Palmer
A1 Aarno Palotie
A1 Christos Pantelis
A1 George N Papadimitriou
A1 Elena Parkhomenko
A1 Carlos Pato
A1 Michele T Pato
A1 Tiina Paunio
A1 Richard Pearson
A1 Psychosis Endophenotypes International Consortium
A1 Diana O Perkins
A1 Roy H Perlis
A1 Amy Perry
A1 Tune H Pers
A1 Tracey L Petryshen
A1 Andrea Pfennig
A1 Marco Picchioni
A1 Olli Pietilainen
A1 Jonathan Pimm
A1 Matti Pirinen
A1 Robert Plomin
A1 Andrew J Pocklington
A1 Danielle Posthuma
A1 James B Potash
A1 Simon C Potter
A1 John Powell
A1 Alkes Price
A1 Ann E Pulver
A1 Shaun M Purcell
A1 Digby Quested
A1 Josep Antoni Ramos-Quiroga
A1 Henrik B Rasmussen
A1 Anna Rautanen
A1 Radhi Ravindrarajah
A1 Eline J Regeer
A1 Abraham Reichenberg
A1 Andreas Reif
A1 Mark A Reimers
A1 Marta Ribases
A1 John P Rice
A1 Alexander L Richards
A1 Michelle Ricketts
A1 Brien P Riley
A1 Fabio Rivas
A1 Margarita Rivera
A1 Joshua L Roffman
A1 Guy A Rouleau
A1 Panos Roussos
A1 Dan Rujescu
A1 Veikko Salomaa
A1 Cristina Sanchez-Mora
A1 Alan R Sanders
A1 Stephen J Sawcer
A1 Ulrich Schall
A1 Alan F Schatzberg
A1 William A Scheftner
A1 Peter R Schofield
A1 Nicholas J Schork
A1 Sibylle G Schwab
A1 Edward M Scolnick
A1 Laura J Scott
A1 Rodney J Scott
A1 Larry J Seidman
A1 Alessandro Serretti
A1 Pak C Sham
A1 Cynthia Shannon Weickert
A1 Tatyana Shehktman
A1 Jianxin Shi
A1 Paul D Shilling
A1 Engilbert Sigurdsson
A1 Jeremy M Silverman
A1 Kang Sim
A1 Claire Slaney
A1 Petr Slominsky
A1 Olav B Smeland
A1 Jordan W Smoller
A1 Hon-Cheong So
A1 Janet L Sobell
A1 Erik Soderman
A1 Christine Soholm Hansen
A1 Chris C A Spencer
A1 Anne T Spijker
A1 David St Clair
A1 Hreinn Stefansson
A1 Kari Stefansson
A1 Stacy Steinberg
A1 Elisabeth Stogmann
A1 Eystein Stordal
A1 Amy Strange
A1 Richard E Straub
A1 John S Strauss
A1 Fabian Streit
A1 Eric Strengman
A1 Jana Strohmaier
A1 T Scott Stroup
A1 Zhan Su
A1 Mythily Subramaniam
A1 Jaana Suvisaari
A1 Dragan M Svrakic
A1 Jin P Szatkiewicz
A1 Szabolcs Szelinger
A1 Avazeh Tashakkori-Ghanbaria
A1 Srinivas Thirumalai
A1 Robert C Thompson
A1 Thorgeir E Thorgeirsson
A1 Draga Toncheva
A1 Paul A Tooney
A1 Sarah Tosato
A1 Timothea Toulopoulou
A1 Richard C Trembath
A1 Jens Treutlein
A1 Vassily Trubetskoy
A1 Gustavo Turecki
A1 Arne E Vaaler
A1 Helmut Vedder
A1 Eduard Vieta
A1 John Vincent
A1 Peter M Visscher
A1 Ananth C Viswanathan
A1 Damjan Vukcevic
A1 John Waddington
A1 Matthew Waller
A1 Dermot Walsh
A1 Muriel Walshe
A1 James TR Walters
A1 Dai Wang
A1 Qiang Wang
A1 Weiqing Wang
A1 Yunpeng Wang
A1 Stanley J Watson
A1 Bradley T Webb
A1 Thomas W Weickert
A1 Daniel R Weinberger
A1 Matthias Weisbrod
A1 Mark Weiser
A1 Thomas Werge
A1 Paul Weston
A1 Pamela Whittaker
A1 Sara Widaa
A1 Durk Wiersma
A1 Dieter B Wildenauer
A1 Nigel M Williams
A1 Stephanie Williams
A1 Stephanie H Witt
A1 Aaron R Wolen
A1 Emily HM Wong
A1 Nicholas W Wood
A1 Brandon K Wormley
A1 Wellcome Trust Case-Control Consortium
A1 Jing Qin Wu
A1 Simon Xi
A1 Wei Xu
A1 Allan H Young
A1 Clement C Zai
A1 Peter Zandi
A1 Peng Zhang
A1 Xuebin Zheng
A1 Fritz Zimprich
A1 Sebastian Zollner
A1 Aiden Corvin
A1 Ayman H Fanous
A1 Sven Cichon
A1 Marcella Rietschel
A1 Elliot S Gershon
A1 Thomas G Schulze
A1 Alfredo B Cuellar-Barboza
A1 Andreas J Forstner
A1 Peter A Holmans
A1 John I Nurnberger
A1 Ole A Andreassen
A1 S Hong Lee
A1 Michael C O’Donovan
A1 Patrick F Sullivan
A1 Roel A Ophoff
A1 Naomi R Wray
A1 Pamela Sklar
A1 Kenneth S Kendler
YR 2017
UL http://biorxiv.org/content/early/2017/08/08/173435.abstract
AB Schizophrenia (SCZ) and bipolar disorder (BD) are highly heritable disorders that share a significant proportion of common risk variation. Understanding the genetic factors underlying the specific symptoms of these disorders will be crucial for improving diagnosis, intervention and treatment. In case-control data consisting of 53,555 cases (20,129 BD, 33,426 SCZ) and 54,065 controls, we identified 114 genome-wide significant loci (GWS) when comparing all cases to controls, of which 41 represented novel findings. Two genome-wide significant loci were identified when comparing SCZ to BD and a third was found when directly incorporating functional information. Regional joint association identified a genomic region of overlapping association in BD and SCZ with disease-independent causal variants indicating a fourth region contributing to differences between these disorders. Regional SNP-heritability analyses demonstrated that the estimated heritability of BD based on the SCZ GWS regions was significantly higher than that based on the average genomic region (91 regions, p = 1.2×10−6) while the inverse was not significant (19 regions, p=0.89). Using our BD and SCZ GWAS we calculated polygenic risk scores and identified several significant correlations with: 1) SCZ subphenotypes: negative symptoms (SCZ, p=3.6×10−6) and manic symptoms (BD, p=2×10−5), 2) BD subphenotypes: psychotic features (SCZ p=1.2×10−10, BD p=5.3×10−5) and age of onset (SCZ p=7.9×10−4). Finally, we show that psychotic features in BD has significant SNP-heritability (h2 snp=0.15, SE=0.06), and a significant genetic correlation with SCZ (rg=0.34) in addition there is a significant sign test result between SCZ GWAS and a GWAS of BD cases contrasting those with and without psychotic features (p=0.0038, one-side binomial test). For the first time, we have identified specific loci pointing to a potential role of 4 genes (DARS2, ARFGEF2, DCAKD and GATAD2A) that distinguish between BD and SCZ, providing an opportunity to understand the biology contributing to clinical differences of these disorders. Our results provide the best evidence so far of genomic components distinguishing between BD and SCZ that contribute directly to specific symptom dimensions.