RT Journal Article
SR Electronic
T1 Can CRISPR-based gene drive be confined in the wild? A question for molecular and population biology
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 173914
DO 10.1101/173914
A1 John M. Marshall
A1 Omar S. Akbari
YR 2017
UL http://biorxiv.org/content/early/2017/08/09/173914.abstract
AB The recent discovery of CRISPR and its application as a gene editing tool has enabled a range of gene drive systems to be engineered with much greater ease. In order for the benefits of this technology to be realized, drive systems must be developed that are capable of both spreading into populations to achieve their desired impact, and being recalled in the event of unwanted consequences or public disfavor. We review the performance of three broad categories of drive systems at achieving these goals - threshold-dependent drives, homing-based drive and remediation systems, and temporally self-limiting systems such as daisy-chain drives.