PT - JOURNAL ARTICLE AU - Adrian Przybylski AU - Björn Thiel AU - Jan Keller-Findeisen AU - Bernd Stock AU - Mark Bates TI - Gpufit: An open-source toolkit for GPU-accelerated curve fitting AID - 10.1101/174110 DP - 2017 Jan 01 TA - bioRxiv PG - 174110 4099 - http://biorxiv.org/content/early/2017/08/10/174110.short 4100 - http://biorxiv.org/content/early/2017/08/10/174110.full AB - We present a general purpose, open-source software library for estimation of non-linear parameters by the Levenberg-Marquardt algorithm. The software, Gpufit, runs on a Graphics Processing Unit (GPU) and executes computations in parallel, resulting in a significant gain in performance. We measured a speed increase of up to 42 times when comparing Gpufit with an identical CPU-based algorithm, with no loss of precision or accuracy. Gpufit is designed such that it is easily incorporated into existing applications or adapted for new ones. Multiple software interfaces, including to C, Python, and Matlab, ensure that Gpufit is accessible from most programming environments. The full source code is published as an open source software repository, making its function transparent to the user and facilitating future improvements and extensions. As a demonstration, we used Gpufit to accelerate an existing scientific image analysis package, yielding significantly improved processing times for super-resolution fluorescence microscopy datasets.