RT Journal Article
SR Electronic
T1 SALMON: inferring protein targets of compounds by network-based analysis of gene transcriptional profiles
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 175364
DO 10.1101/175364
A1 Heeju Noh
A1 Jason E. Shoemaker
A1 Rudiyanto Gunawan
YR 2017
UL http://biorxiv.org/content/early/2017/08/11/175364.abstract
AB We present SALMON, a method for identifying protein targets of compounds using cell-type specific protein-gene networks and gene transcriptional profiles. For benchmark datasets from three drug treatment studies, SALMON was able to provide highly accurate target predictions, with an average area under receiver operating characteristic of 0.82. SALMON was also able to reveal the mechanism of action of DNA-damaging compounds in NCI-DREAM drug synergy study with high sensitivity and specificity.