RT Journal Article SR Electronic T1 Single-cell RNA sequencing reveals cell-type specific cis-eQTLs in peripheral blood mononuclear cells JF bioRxiv FD Cold Spring Harbor Laboratory SP 177568 DO 10.1101/177568 A1 van der Wijst, M.G.P. A1 Brugge, H. A1 de Vries, D.H. A1 Franke, L.H. YR 2017 UL http://biorxiv.org/content/early/2017/08/17/177568.abstract AB Most disease-associated genetic risk factors are regulatory. Here, we generated single-cell RNA-seq data of ∼25,000 peripheral blood mononuclear cells from 45 donors to identify how genetic variants affect gene expression. We validated this approach by replicating previously published whole blood RNA-seq cis-expression quantitative trait loci effects (cis-eQTLs), but also identified new cell type-specific cis-eQTLs. These eQTLs give additional insight into the downstream consequences of genetic risk factors for immune-mediated diseases.