RT Journal Article
SR Electronic
T1 RNA-dependent intergenerational inheritance of enhanced synaptic plasticity after environmental enrichment
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 178814
DO 10.1101/178814
A1 Eva Benito
A1 Cemil Kerimoglu
A1 Binu Ramachandran
A1 Qihui Zhou
A1 Tonatiuh Pena
A1 Vincenzo Capece
A1 Gaurav Jain
A1 Susanne Burkhardt
A1 Roman Stilling
A1 Dieter Edbauer
A1 Camin Dean
A1 André Fischer
YR 2017
UL http://biorxiv.org/content/early/2017/08/20/178814.abstract
AB Physical exercise in combination with cognitive training is known to enhance synaptic plasticity and lower the risk for various complex diseases including Alzheimer’s disease. Here we show that exposure of adult male mice to an environmental enrichment paradigm leads to long-lasting enhancement of synaptic plasticity that is also passed on to the next generation. We show that the effect is mediated through sperm RNA and is explained by microRNAs 212/132. In conclusion, our study reports intergenerational inheritance of an acquired cognitive benefit and points to specific microRNAs as candidates mechanistically involved in this type of transmission.