TY - JOUR T1 - Circuit robustness to temperature perturbation is altered by neuromodulators JF - bioRxiv DO - 10.1101/178764 SP - 178764 AU - Sara A. Haddad AU - Eve Marder Y1 - 2017/01/01 UR - http://biorxiv.org/content/early/2017/08/21/178764.abstract N2 - In the ocean, the crab, Cancer borealis, is subject to daily and seasonal temperature changes. Previous work, done in the presence of descending modulatory inputs, had shown that the pyloric rhythm of the crab increases in frequency as temperature increases, but maintains its characteristic phase relationships until it “crashes” at extreme high temperatures. To study the interaction between neuromodulators and temperature perturbations, we studied the effects of temperature on preparations from which the descending modulatory inputs were removed. Under these conditions the pyloric rhythm was destabilized. We then studied the effects of temperature on preparations in the presence of oxotremorine, proctolin, and serotonin. Oxotremorine and proctolin enhanced the robustness of the pyloric rhythm, while serotonin made the rhythm less robust. These experiments reveal considerable animal-to-animal diversity in their crash stability, consistent with the interpretation that cryptic differences in many cell and network parameters are revealed by extreme perturbations. ER -