RT Journal Article
SR Electronic
T1 Effects of partial selfing on the equilibrium genetic variance, mutation load and inbreeding depression under stabilizing selection
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 180000
DO 10.1101/180000
A1 Diala Abu Awad
A1 Denis Roze
YR 2017
UL http://biorxiv.org/content/early/2017/08/24/180000.abstract
AB The mating system of a species is expected to have important effects on its genetic diversity. In this paper, we explore the effects of partial selfing on the equilibrium genetic variance Vg, mutation load L and inbreeding depression δ under stabilizing selection acting on a arbitrary number n of quantitative traits coded by biallelic loci with additive effects. Three different regimes are observed. When the U/n ratio is low (where U is the total mutation rate on selected traits) and effective recombination rates are sufficiently high, genetic associations between loci are negligible and the mutation load and inbreeding depression are well predicted by approximations based on single-locus models. For higher values of U/n and/or lower effective recombination, moderate genetic associations generated by epistasis tend to increase Vg, L and δ, this regime being well predicted by approximations including the effects of pairwise associations between loci. For yet higher values of U/n and/or lower effective recombination, a different regime is reached under which the maintenance of coadapted gene complexes reduces Vg, L and δ. Simulations indicate that the values of Vg, L and δ are little affected by assumptions regarding the number of possible alleles per locus.